Aim Alpha-1 antitrypsin deficiency is an autosomal co-dominant condition that predisposes
individuals to early-onset emphysema. As with COPD, AATD-COPD is associated with …

Chronic obstructive pulmonary disease (COPD) is a multicomponent condition that is
estimated to become the third leading cause of death in 2020. The ECLIPSE (Evaluation of …

Abstract Alpha-1 antitrypsin deficiency (AATD) predisposes to emphysema, liver disease,
and panniculitis. This emphysema risk naturally invites a comparison between “regular” …

Abstract Background Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition
caused by mutations of the SERPINA1 gene that is associated with the development of a …

The abundant serum protein alpha-1 antitrypsin (AAT) is the prototype chronic obstructive
pulmonary disease (COPD) biomarker. AAT is an antiprotease which inhibits …

Abstract Alpha-1 antitrypsin deficiency (AATD) is an important risk factor for development of
chronic obstructive pulmonary disease (COPD). Patients with AATD classically develop a …

Background The new GOLD (Global Initiative for Chronic Obstructive Lung Disease) strategy
recommends use of the COPD Assessment Test (CAT) or modified Medical Research …

Background A deficiency in alpha-1 antitrypsin (A1AD) leads to increased activity of
proteolytic enzymes. The consequence is a damage of airways and alveoli and, ultimately …

BACKGROUND: The frequency, characteristics and impact of acute exacerbations in
patients with alpha-1 antitrypsin deficiency (AATD) and COPD who are on intravenous alpha …

Background Alpha-1 antitrypsin deficiency (AATD) is a rare genetic condition predisposing
individuals to chronic obstructive pulmonary disease (COPD). The treatment is generally …