Anticancer carbonic anhydrase inhibitors: a patent and literature update 2018-2022
Introduction Cancer affects an increasing number of patients each year with an
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …
A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Carbonic anhydrase IX inhibitors in cancer therapy: an update
CT Supuran, JY Winum - Future medicinal chemistry, 2015 - Taylor & Francis
Carbonic anhydrases (CAs; EC 4.2. 1.1) are well known zinc metalloproteins involved in the
catalysis of a very simple but essential physiological reaction: carbon dioxide hydration to …
catalysis of a very simple but essential physiological reaction: carbon dioxide hydration to …
Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008–2018)
A Nocentini, CT Supuran - Expert Opinion on Therapeutic Patents, 2018 - Taylor & Francis
Introduction: Human carbonic anhydrases (CA, EC 4.2. 1.1) IX and XII are tumor-associated
proteins, being part of the molecular machinery that tumor cells build as adaptive responses …
proteins, being part of the molecular machinery that tumor cells build as adaptive responses …
Anticancer carbonic anhydrase inhibitors: a patent review (2008–2013)
Introduction: Human carbonic anhydrases (EC 4.2. 1.1) IX (hCA IX) and XII (hCA XII) are two
tumor-associated proteins, being overexpressed in many tumors and involved in critical …
tumor-associated proteins, being overexpressed in many tumors and involved in critical …
[HTML][HTML] Tumor associated carbonic anhydrase inhibitors: rational approaches, design strategies, structure activity relationship and mechanistic insights
The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …
therapeutic targets has urged rigorous research into the development of potent and selective …
Cancer drug development of carbonic anhydrase inhibitors beyond the active site
Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce
bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases …
bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases …
Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
Targeting tumour associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII is
now considered as a pertinent approach for the development of new cancer therapeutics …
now considered as a pertinent approach for the development of new cancer therapeutics …
How many carbonic anhydrase inhibition mechanisms exist?
CT Supuran - Journal of enzyme inhibition and medicinal chemistry, 2016 - Taylor & Francis
Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …
Mapping selective inhibition of the cancer-related carbonic anhydrase IX using structure–activity relationships of glucosyl-based sulfamates
BP Mahon, CL Lomelino, J Ladwig… - Journal of Medicinal …, 2015 - ACS Publications
Inhibition of human carbonic anhydrase IX (hCA IX) has shown to be therapeutically
advantageous for treating many types of highly aggressive cancers. However, designing …
advantageous for treating many types of highly aggressive cancers. However, designing …