Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing
tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral …

Background: Breakdown of the mucosal barrier resulting in mucositis is a common adverse
event in patients with cancer receiving chemotherapy and radiation. Many studies have …

Background Glutamine is the primary fuel for the gastrointestinal epithelium and maintains
the mucosal structure. Oncologists frequently encounter oral mucositis, which can cause …

Mucositis is a common toxicity of cancer chemotherapy. Glutamine appears to be the major
energy source for intestinal epithelium, and animal studies have suggested that dietary …

OBJECTIVES: Three series of studies investigated whether 1) glutamine deficiency occurs in
tumor-bearing rats, 2) glutamine supplementation improves protein metabolism during …

BACKGROUND Mouth sores and/or difficulty swallowing are common and painful
consequences of cytotoxic chemotherapy for cancer. In previous studies oral glutamine was …

Goals of the work. Malignancy produces a state of physiologic stress that is characterized by
a relative deficiency of glutamine, a condition that is further exacerbated by the effects of …

Background In hypermetabolic situations, glutamine is intensively used by rapidly dividing
cells such as enterocytes, lymphocytes, and fibroblasts as nitrogen source and/or alternative …

In animal studies, glutamine (Gln) reduces chemotherapy-associated mucositis and mucosal
atrophy. Therefore, this study examined the protective effects of a parenteral Gln …

Treatment of cancer is associated with short-and long-term side-effects. Cancer produces a
state of glutamine deficiency, which is further aggravated by toxic effects of …