Next-generation cancer organoids
Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …
cancer heterogeneity and its implications for personalized medicine. These advancements …
Organoids in cancer research
J Drost, H Clevers - Nature Reviews Cancer, 2018 - nature.com
The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …
new avenues for the development of novel, more physiological human cancer models. Such …
[PDF][PDF] A pan-cancer organoid platform for precision medicine
BM Larsen, M Kannan, LF Langer, BD Leibowitz… - Cell reports, 2021 - cell.com
Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer
biology and develop novel precision medicine therapeutics. However, utilizing TOs for …
biology and develop novel precision medicine therapeutics. However, utilizing TOs for …
[HTML][HTML] Patient-derived organoids in precision medicine: drug screening, organoid-on-a-chip and living organoid biobank
Z Zhou, L Cong, X Cong - Frontiers in Oncology, 2021 - frontiersin.org
Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …
stably retain key characteristics of the respective organs. Organoids can be generated from …
Organoid models for cancer research
H Clevers, DA Tuveson - Annual Review of Cancer Biology, 2019 - annualreviews.org
Organoid cultures have emerged as powerful model systems accelerating discoveries in
cellular and cancer biology. These three-dimensional cultures are amenable to diverse …
cellular and cancer biology. These three-dimensional cultures are amenable to diverse …
Organoids: An intermediate modeling platform in precision oncology
Cancer harbors variable heterogeneity and plasticity. Thus far, our comprehension is greatly
based on cell lines, organoids, and patient-derived tumor xenografts (PDTXs). Organoids …
based on cell lines, organoids, and patient-derived tumor xenografts (PDTXs). Organoids …
Applications of organoids for cancer biology and precision medicine
YH Lo, K Karlsson, CJ Kuo - Nature Cancer, 2020 - nature.com
Organoid technologies enable the creation of in vitro physiologic systems that model tissues
of origin more accurately than classical culture approaches. Seminal characteristics of these …
of origin more accurately than classical culture approaches. Seminal characteristics of these …
[HTML][HTML] Emerging organoid models: leaping forward in cancer research
Cancer heterogeneity is regarded as the main reason for the failure of conventional cancer
therapy. The ability to reconstruct intra-and interpatient heterogeneity in cancer models is …
therapy. The ability to reconstruct intra-and interpatient heterogeneity in cancer models is …
[PDF][PDF] Tumor organoids as a pre-clinical cancer model for drug discovery
Tumor organoids are 3D cultures of cancer cells that can be derived on an individual patient
basis with a high success rate. This creates opportunities to build large biobanks with …
basis with a high success rate. This creates opportunities to build large biobanks with …
Organoid cultures for the analysis of cancer phenotypes
Preclinical models of cancer are essential for a basic understanding of cancer biology and
its translation into efficient treatment options for affected patients. Cancer cell lines and …
its translation into efficient treatment options for affected patients. Cancer cell lines and …