Aims Adult T-cell leukemia (ATL) is a mature T-cell neoplasm associated with human T-cell
lymphotropic virus (HTLV-1) infection. Major limitations in Doxorubicin (Dox) chemotherapy …

Introduction: Adult T-cell leukemia (ATL) is an aggressive form of malignancy caused by
human T-cell lymphotropic virus 1 (HTLV-1). Currently, there is no effective treatment for …

Aims To reduce the dose of arsenic used against human T-cell leukemia/lymphoma and to
sensitize cells to drug treatment, we combined arsenic/interferon-alpha (As/IFN-α) with …

We show that HTLV-1 negative leukemia cells are more sensitive to TQ due to higher levels
of drug-induced reactive oxygen species (ROS). PreG1 population in HTLV-1 negative …

There has been a growing interest in naturally occurring compounds from traditional
medicine with anti-cancer potential. Nigella sativa (black seed) is one of the most widely …

Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in
some elderly human T-cell leukemia virus (HTVL-1) carriers. ATLL has a poor prognosis …

Due to narrow therapeutic window of cancer therapeutic agents and the development of
resistance against these agents, there is a need to discover novel agents to treat breast …

Thymoquinone (TQ), a natural anticancer agent exerts cytotoxic effects on several tumors by
targeting multiple pathways, including apoptosis. Difluoromethylornithine (DFMO), an …

We describe to the findings of cellular activity in RAW 264.7 leukemia cells and CRL 1764
Rat2 cardiomyocyte when subjected to thymoquinone, doxorubicin and in combination …

Doxorubicin (DOX) has a wide spectrum of antitumor activity with dose-related cardiotoxicity
as a major side effect. This cardiotoxicity has been suggested to result from the generation of …