Dynamic control of peroxisome proliferation is integral to the peroxisome's many functions.
The endoplasmic reticulum (ER) serves as a source of preperoxisomal vesicles (PPVs) that …

Peroxisomes are single membrane-bound organelles present in virtually all eukaryotes.
These organelles participate in several important metabolic processes, and defects in …

Pex19p, a soluble cytoplasmic transport protein, is required for the traffic of the peroxisomal
membrane proteins Pex3p and Pex15p from the endoplasmic reticulum (ER) to the …

Peroxisomes are essential cellular organelles involved in lipid metabolism. Patients affected
by severe peroxisome biogenesis disorders rarely survive their first year. Genetic screens in …

During de novo peroxisome biogenesis, importomer complex proteins sort via two
preperoxisomal vesicles (ppVs). However, the sorting mechanisms segregating peroxisomal …

Peroxisomes proliferate by growth and division of pre-existing peroxisomes or could arise
de novo. Though the de novo pathway of peroxisome biogenesis is a more recent discovery …

During the past few years, we have witnessed a paradigm shift in our long-standing concept
of peroxisome biogenesis. Recent biochemical and morphological studies have revealed a …

As a rule, organelles in eukaryotic cells can derive only from pre-existing organelles.
Peroxisomes are unique because they acquire their lipids and membrane proteins from the …

Two pathways have been identified for peroxisome formation:(i) growth and division and (ii)
de novo synthesis. Recent experiments determined that peroxisomes originate at the …

In the yeast Hansenula polymorpha the peroxisomal membrane protein Pex11 and three
endoplasmic reticulum localized proteins of the Pex23 family (Pex23, Pex24 and Pex32) are …