The melanocytes in the mammalian eye have been thought to produce melanin only during
fetal development and in the very young individual. The recent discovery that latanoprost, a …

Latanoprost, the active principle of XalatanR eye drops, is a prostaglandin F2α analogue in
widespread use for the treatment of glaucoma. During chronic treatment with the drug, an …

Latanoprost, a phenyl-substituted analogue of prostaglandin F2α administered as eye
drops, in-duces increased melanogenesis in the iridial melanocytes of monkeys. Similar …

Purpose The authors sought to investigate the cellular mechanism of melanogenesis by
prostaglandin antiglaucomatous compounds, isopropyl unoprostone (referred to as …

The prostaglandin F2α derivative, latanoprost (LT), used in glaucoma treatment, can induce
pigmentation in irises of patients with hazel or heterochromatic eye colour. The mechanism …

Whether melanogenesis occurs in adult eyes is still a matter of controversy. It has been
widely held that the pigment epithelial cells are fully melanized at birth, and that the uveal …

Several prostaglandin analogues used for glaucoma treatment cause increased
pigmentation of the iris. The purpose of the present study was investigate whether …

The effect of various prostaglandins on the growth, melanogenesis and dendrification of
cultured iridal melanocytes were studied. Iridal melanocytes were isolated and cultured with …

Topical use of latanoprost for glaucoma can lead to an increase in iris and eye lash
pigmentation but the precise mechanism is unclear. To study the possible effect of this drug …

The PGF2α derivative, latanoprost, is a recent anti-glaucoma drug that has been reported to
induce a discrete incidence of increased iris pigmentation in men. The present experiments …