Atypical Hyperplasia of the Breast — Risk Assessment and Management Options | New England
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Purpose Atypical hyperplasia is a well-recognized risk factor for breast cancer, conveying an
approximately four-fold increased risk. Data regarding long-term absolute risk and factors for …

Atypical hyperplasia is a high-risk premalignant lesion of the breast, but its biology is poorly
understood. Many believe that atypical ductal hyperplasia (ADH) is a direct precursor for low …

BACKGROUND. Atypical hyperplasia (AH) in a benign breast biopsy is associated with an
increased breast cancer risk. However, the influence of the histologic type of AH on the …

We recently reported'the utility of histopathologic patterns in breast biopsies as predictors of
future breast cancer risk. The acceptance of an intermediate category between carcinomas …

Background. Recent studies concerning an association between benign breast diseases
and risk of subsequent breast cancer have focused on benign proliferative lesions …

Epidemiological studies using the histological classification of Page for benign breast
disease consistently demonstrate a positive association between atypical hyperplasia and …

The hypothetical multistep model for breast carcinogenesis indicates that invasive
carcinoma arises via a series of intermediate hyperplastic lesions through various grades of …

Benign breast disease (BBD) is a broad category of diagnoses reported to convey a variable
degree of increased risk of developing breast cancer. A meta-analysis of the existing …

Epithelial hyperplasia of the breast carries an increased likelihood of carcinoma
development, with most lesions best understood as markers of higher risk. The indication of …