Current standards for methodological rigor and trial reporting underscore the critical issue of
statistical power. Still, the chance of detecting most effects reported in randomized controlled …

Objectives To study the statistical power of randomized clinical trials and examine
developments over time. Study Design and Setting We analyzed the statistical power in …

We were gratified to see in the January 15, 2005, issue of the Journal further discussion of
the ethics of conducting clinical trials that are underpowered to reliably detect clinically …

Background The belief remains widespread that medical research studies must have
statistical power of at least 80% in order to be scientifically sound, and peer reviewers often …

Background The published clinical research literature may be distorted by the pursuit of
statistically significant results. Purpose We aimed to develop a test to explore biases …

Much hand-wringing has been stimulated by the reflection that reports of clinical studies
often misinterpret and misrepresent the findings of the statistical analyses. Recent proposals …

In their article entitled,“Ethics and Sample Size,” Bacchetti et al.(1) provide a spirited
justification, based on ethical considerations, for the conduct of clinical trials that may have …

Background. The randomized controlled clinical trial is currently the most scientific method
for evaluating the effect of medical interventions. The sample size of a trial is crucial for …

While I welcome the call to abandon statistical significance (Wasserstein, Schirm, and Lazar
2019), there is another arbitrary cutoff, power≥ 80%, that is also quite harmful (Bacchetti …

There is debate whether clinical trials with suboptimal power are justified and whether
results from large studies are more reliable than the (combined) results of smaller trials. We …