Neuroinflammation is a well-characterized pathophysiology occurring in association with the
progression of Parkinson's disease. Characterizing the cellular and molecular basis of …

Highlights•Host-derived molecules (eg β-amyloid, tau) trigger NLRP3 inflammasome
signaling.•TNF, ATP, serum amyloid A and the microbiome regulate NLRP3 inflammasome …

Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …

Neuroinflammation is a key pathological feature in neurological diseases, including
Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing …

The innate immune system and inflammatory response in the brain have critical impacts on
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …

Neurodegenerative diseases are a group of neuronal disorders caused by progressive
neuronal cell death in different regions of the human brain. Alzheimer's disease (AD) and …

Inflammasomes are supramolecular protein complexes implicated in the detection of
pathogens or danger-associated molecules and are responsible for mounting the first line of …

Parkinson's disease (PD) is mediated, in part, by intraneuronal accumulation of α-synuclein
aggregates andsubsequent death of dopamine (DA) neurons in the substantia nigra pars …