Metabolomic evolution of the postpartum dairy cow uterus

N Aranciaga, AB Ross, JD Morton… - Molecular …, 2023 - Wiley Online Library
High rates of early pregnancy loss are a critical issue in dairy herds, particularly in seasonal,
grazing systems. Components of the uterine luminal fluid (ULF), on which the early embryo …

Changes in the uterine metabolome of the cow during the first 7 days after estrus

P Tríbulo, L Balzano‐Nogueira… - Molecular …, 2019 - Wiley Online Library
The uterine microenvironment during the first 7 days after ovulation accommodates and
facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for …

Proteomic determinants of uterine receptivity for pregnancy in early and mid-postpartum dairy cows

N Aranciaga, JD Morton, E Maes… - Biology of …, 2021 - academic.oup.com
Dairy cow subfertility is a worldwide issue arising from multiple factors. It manifests in> 30%
early pregnancy losses in seasonal pasture-grazed herds, especially when cows are …

Understanding the uterine environment in early pregnancy in cattle: How have the omics enhanced our knowledge?

CA Simintiras, N Forde - Animal Reproduction (AR), 2018 - animal-reproduction.org
Early pregnancy loss in cattle can be attributed to a myriad of sources. One key factor that
can influence early pregnancy success or loss is the influence and interactions between the …

Uterine lumen fluid is metabolically semi-autonomous

CA Simintiras, JN Drum, H Liu, M Sofia Ortega… - Communications …, 2022 - nature.com
Uterine lumen fluid (ULF) is central to successful pregnancy establishment and
maintenance, and impacts offspring wellbeing into adulthood. The current dogma is that ULF …

Progesterone alters the bovine uterine fluid lipidome during the period of elongation

CA Simintiras, JM Sánchez, M McDonald… - …, 2019 - rep.bioscientifica.com
Successful bovine pregnancy establishment hinges on conceptus elongation, a key
reproductive phenomenon coinciding with the period during which most pregnancies fail …

Pre-estrus progesterone does not affect post-estrus luminal metabolome in cross-bred beef cows

FACC Silva, T Martins, M Sponchiado… - …, 2023 - rep.bioscientifica.com
In brief The concentration of progesterone through the estrous cycle modulates uterine
function to affect the luminal metabolome. This paper reports that the dynamic changes in …

Follicular fluid metabolite changes in dairy cows with inactive ovary identified using untargeted metabolomics

YL Bai, F Zhang, HY Zhang, C Xu… - BioMed Research …, 2020 - Wiley Online Library
The metabolism of dairy cows with inactive ovaries differs from that of healthy dairy cows.
However, the molecular mechanisms underpinning these physiological and metabolic …

Analysis of the uterine lumen in fertility-classified heifers: II. Proteins and metabolites

JGN Moraes, SK Behura, JV Bishop… - Biology of …, 2020 - academic.oup.com
Survival and growth of the bovine conceptus is dependent on endometrial secretions or
histotroph. Previously, serial blastocyst transfer was used to classify heifers as high fertile …

Targeted metabolomics: New insights into pathobiology of retained placenta in dairy cows and potential risk biomarkers

E Dervishi, G Zhang, R Mandal, DS Wishart, BN Ametaj - Animal, 2018 - cambridge.org
A targeted quantitative metabolomics approach was used to study temporal changes of
serum metabolites in cows that normally released their fetal membranes and those that …