Statistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid
tumor characterized by high heterogeneity and the presence of a complex extracellular …

Cancer is the leading cause of death worldwide and its incidence is expected to rise.
Despite overwhelming efforts to design innovative preclinical models that faithfully replicate …

Pancreatic ductal adenocarcinoma (PDAC) is a malignant epithelial neoplasm, recently
estimated to be the third leading cause of death in the United States. Too little is known so …

Considering the great influence of tumour microenvironment on the development and
metastasis of cancer progression, three dimensional (3D) culture models have become …

Experimental in vitro models that capture pathophysiological characteristics of human
tumours are essential for basic and translational cancer biology. Here, we describe a fully …

Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer
mortality in the United States, with a 5-year survival of∼ 8%. PDAC is characterized by a …

Biomimetic 3D models emerged some decades ago to address 2D cell culture limitations in
the field of replicating biological phenomena, structures or functions found in nature. The …

Three-dimensional (3D) cancer models are invaluable tools designed to study tumour
biology and new treatments. Pancreatic ductal adenocarcinoma (PDAC), one of the …

Improving the translational efficiency of anti-cancer agents requires advancements on many
fronts, including the continued development of three-dimensional (3D) tumor models that …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer
and has seen only modest improvements in patient survival rate over the past few decades …