Background Protein antigens and their specific epitopes are formulation targets for epitope-
based vaccines. A number of prediction servers are available for identification of peptides …

Background Initiation and regulation of immune responses in humans involves recognition
of peptides presented by human leukocyte antigen class II (HLA-II) molecules. These …

Major histocompatibility complex class II (MHC‐II) molecules are expressed on the surface
of professional antigen‐presenting cells where they display peptides to T helper cells, which …

Background A variety of methods for prediction of peptide binding to major histocompatibility
complex (MHC) have been proposed. These methods are based on binding motifs, binding …

Motivation: Various methods have been proposed to predict the binding affinities of peptides
to Major Histocompatibility Complex class I (MHC-I) molecules based on experimental …

The identification of MHC class II restricted peptide epitopes is an important goal in
immunological research. A number of computational tools have been developed for this …

Several accurate prediction systems have been developed for prediction of class I major
histocompatibility complex (MHC): peptide binding. Most of these are trained on binding …

Background It is important to accurately determine the performance of peptide: MHC binding
predictions, as this enables users to compare and choose between different prediction …

Motivation: Numerous in silico methods predicting peptide binding to major
histocompatibility complex (MHC) class I molecules have been developed over the last …

Background Peptides derived from endogenous antigens can bind to MHC class I
molecules. Those which bind with high affinity can invoke a CD8+ immune response …