Electron micrographs first confirmed that the eukaryotic genome is organized into repeating
disk-shaped nucleosomal units composed of histones and their associated DNA. Those …

The nucleosomal subunit organization of chromatin provides a multitude of functions.
Nucleosomes elicit an initial∼ 7-fold linear compaction of genomic DNA. They provide a …

Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

It is now widely recognized that the packaging of genomic DNA together with core histones,
linker histones, and other functional proteins into chromatin profoundly influences nuclear …

Nucleosomes are fundamental units of chromatin compaction, which organize∼ 200 DNA
base pairs using an octamer of histone proteins. Their ubiquitous presence in the cell …

Assembly, mobilization and disassembly of nucleosomes can influence the regulation of
gene expression and other processes that act on eukaryotic DNA. Distinct nucleosome …

Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

Eukaryotes associate their genomes with histone proteins, forming nucleosome particles.
Nucleosomes regulate and protect the genetic information. They often assemble into evenly …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …