Recent advances in technologies for developing drugs against Chlamydia pneumoniae

L Hanski, PM Vuorela - Expert opinion on drug discovery, 2014 - Taylor & Francis
Introduction: The unique morphological characteristics, capacity of manipulating host cell
function and association with chronic inflammatory diseases represent the features of …

Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors

L Hanski, P Vuorela - Microorganisms, 2016 - mdpi.com
Throughout its known history, the gram-negative bacterium Chlamydia pneumoniae has
remained a challenging target for antibacterial chemotherapy and drug discovery. Owing to …

Strategic targeting of essential host-pathogen interactions in chlamydial disease

BK Coombes, DL Johnson… - Current Drug Targets …, 2002 - ingentaconnect.com
The chlamydiae are obligate intracellular gram-negative bacteria that are exquisitely
adapted for exploitation of their hosts and contribute to a wide range of acute and chronic …

Advances in the management of Chlamydia pneumoniae infections

MR Hammerschlag - Expert Review of Anti-Infective Therapy, 2003 - Taylor & Francis
One of the major characteristics of Chlamydia spp. is its ability to cause prolonged, often
subclinical infections. Chronic, persistent infection with Chlamydia pneumoniae has been …

[HTML][HTML] Molecular pathogenesis of chronic Chlamydia pneumoniae infection: a brief overview

JM Kern, V Maass, M Maass - Clinical microbiology and infection, 2009 - Elsevier
Owing to its unique host cell-dependent development cycle, Chlamydia pneumoniae
occupies an intracellular niche that enables the bacterium to survive and to multiply …

Chlamydia pneumoniae: modern insights into an ancient pathogen

E Roulis, A Polkinghorne, P Timms - Trends in microbiology, 2013 - cell.com
Chlamydia pneumoniae is an enigmatic human and animal pathogen. Originally discovered
in association with acute human respiratory disease, it is now associated with a remarkably …

Emerging strategies in the diagnosis, prevention and treatment of chlamydial infections

OS Mahdi, GI Byrne, M Kalayoglu - Expert Opinion on Therapeutic …, 2001 - Taylor & Francis
Chlamydial infections cause a spectrum of diseases affecting millions of individuals
worldwide. Chlamydia trachomatis is the most common sexually transmitted bacterium and …

Transformation of Chlamydia: current approaches and impact on our understanding of chlamydial infection biology

M Rahnama, KA Fields - Microbes and infection, 2018 - Elsevier
The intonation “The king is dead, long live the king” aptly describes the state of Chlamydia
research. Genetic-based approaches are rapidly replacing correlative strategies to provide …

The potential for vaccine development against chlamydial infection and disease

RC Brunham, DJ Zhang, X Yang… - The Journal of …, 2000 - academic.oup.com
Chlamydia trachomatis and Chlamydia pneumoniae appear to share a common
immunobiology with about 80% of their protein coding genes being orthologs. Progress in …

[PDF][PDF] Chlamydia pneumoniae as a respiratory pathogen

DL Hahn, AA Azenabor, WL Beatty, GI Byrne - Front Biosci, 2002 - article.imrpress.com
[Frontiers in Bioscience 7, e66-76, March 1, 2002] 66 CHLAMYDIA PNEUMONIAE AS A
RESPIRATORY PATHOGEN David L. Hahn1, Anthony A. Page 1 [Frontiers in Bioscience 7 …