Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

X Yan, B Tang, B Chen, Y Shan, H Yang - Elife, 2019 - elifesciences.org
As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Li
et al., 2015), that described how we intended to replicate selected experiments from the …

Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

J Li, M Lam, Reproducibility Project: Cancer Biology - Elife, 2015 - elifesciences.org
The Reproducibility Project: Cancer Biology seeks to address growing concerns about
reproducibility in scientific research by conducting replications of selected experiments from …

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

C Liu, K Kelnar, B Liu, X Chen, T Calhoun-Davis, H Li… - Nature medicine, 2011 - nature.com
Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and
metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs,,,, and …

MicroRNA-34a, prostate cancer stem cells, and therapeutic development

W Li, X Liu, EM Dougherty, DG Tang - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer is still the most common cancer among men in the US.
Current standard-of-care therapies for metastatic castration-resistant prostate cancer can …

[HTML][HTML] Inactivation of AR and Notch-1 signaling by miR-34a attenuates prostate cancer aggressiveness

M Kashat, L Azzouz, SH Sarkar, D Kong… - American journal of …, 2012 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is the second leading cause of cancer related death in men in the
United States, suggesting that novel molecular targets as well as the development of agents …

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

C Liu, R Liu, D Zhang, Q Deng, B Liu, HP Chao… - Nature …, 2017 - nature.com
MicroRNAs play important roles in regulating tumour development, progression and
metastasis. Here we show that one of the miR-200 family members, miR-141, is under …

The tumour suppressor miR-34c targets MET in prostate cancer cells

Z Hagman, BS Haflidadottir, M Ansari… - British journal of …, 2013 - nature.com
Background: The microRNA, miR-34c, is a well-established regulator of tumour suppression.
It is downregulated in most forms of cancers and inhibits malignant growth by repressing …

Expression of microRNA-379 reduces metastatic spread of prostate cancer

JR Cassidy, G Voss, KR Underbjerg, M Persson… - Frontiers in …, 2023 - frontiersin.org
Introduction Prostate cancer (PCa) is the most common type of cancer in males, and the
metastatic form is a leading cause of death worldwide. There are currently no curative …

Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes

F Takeshita, L Patrawala, M Osaki, R Takahashi… - Molecular Therapy, 2010 - cell.com
Recent reports have linked the expression of specific microRNAs (miRNAs) with
tumorigenesis and metastasis. Here, we show that microRNA (miR)-16, which is expressed …

[HTML][HTML] microRNA-323 upregulation promotes prostate cancer growth and docetaxel resistance by repressing p73

Q Gao, J Zheng - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Our previous work has demonstrated that miR-323 enhances tumor angiogenesis in
prostate cancer. In the present study, we sought to determine the function of miR-323 in …