Opposing PKA and Hog1 signals control the post‐transcriptional response to glucose availability in Cryptococcus neoformans

D Banerjee, ALM Bloom… - Molecular …, 2016 - Wiley Online Library
The pathogenic fungus Cryptococcus neoformans must adapt to glucose‐limited conditions
in the lung and glucose replete conditions upon dissemination to the brain. We report that …

Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans

J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …

[HTML][HTML] A Conserved Gcn2-Gcn4 Axis Links Methionine Utilization and the Oxidative Stress Response in Cryptococcus neoformans

AK Stovall, CM Knowles, MC Kalem… - Frontiers in fungal …, 2021 - frontiersin.org
The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of
gene regulation to adapt to stressors it encounters in the human host, such as oxidative …

[HTML][HTML] Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection

G Hu, PY Cheng, A Sham, JR Perfect… - Molecular …, 2008 - Wiley Online Library
The pathogenic fungus Cryptococcus neoformans generally initiates infection in mammalian
lung tissue and subsequently disseminates to the brain. We performed serial analysis of …

Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host

MS Price, M Betancourt-Quiroz, JL Price, DL Toffaletti… - MBio, 2011 - Am Soc Microbiol
Cryptococcus neoformans is an important fungal pathogen of immunocompromised
individuals, with a close relative, Cryptococcus gattii, emerging as a serious threat for the …

Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans

ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …

[HTML][HTML] Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation

X Xu, J Lin, Y Zhao, E Kirkman, YS So, YS Bahn… - PLoS …, 2017 - journals.plos.org
Morphotype switch is a cellular response to external and internal cues. The Cryptococcus
neoformans species complex can undergo morphological transitions between the yeast and …

The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

BJ Chadwick, T Pham, X Xie, LC Ristow, DJ Krysan… - Elife, 2022 - elifesciences.org
The environmental pathogen Cryptococcus neoformans claims over 180,000 lives each
year. Survival of this basidiomycete at host CO2 concentrations has only recently been …

Role of glucose in the expression of Cryptococcus neoformans antiphagocytic protein 1, App1

V Williams, M Del Poeta - Eukaryotic cell, 2011 - Am Soc Microbiol
The cryptococcus-specific protein antiphagocytic protein 1 (App1) regulates Cryptococcus
neoformans virulence by controlling macrophage-driven fungal phagocytosis. This is …