Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

One of the most consistent findings in the depression literature is that stressful life events
predict the onset and course of depressive episodes. Cognitive and biological responses to …

Previously, authors have reviewed the evidence pertaining to a wide range of
neurochemical, neuroendocrine, neurophysiological, and structural correlates of …

Abstract Major Depressive Disorder (MDD) is one of the most common and debilitating
mental disorders; however, its etiology remains unclear. This paper aims to summarize the …

Major depressive disorder is a serious medical illness which is responsible for considerable
morbidity and disability. Despite decades of research, the neural basis for depression is still …

The past 5 years have seen unprecedented advances in our knowledge about the
neurobiology of depression. Significant breakthroughs have been made in genomics …

Cognitive theories of depression posit that people's thoughts, inferences, attitudes, and
interpretations, and the way in which they attend to and recall information, can increase their …

Due to the clinical and etiological heterogeneity of major depressive disorder, it has been
difficult to elucidate its pathophysiology. Current neurobiological theories with the most valid …

BACKGROUND Research on the neurobiology of depression began in earnest in the late
1950s, when converging lines of evidence pointed to the possibility of dysfunction of CNS …

Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …