Adjuvants: Classification, Modus Operandi, and Licensing

JS Apostolico, VAS Lunardelli… - Journal of …, 2016 - Wiley Online Library
Vaccination is one of the most efficient strategies for the prevention of infectious diseases.
Although safer, subunit vaccines are poorly immunogenic and for this reason the use of …

[HTML][HTML] Recent advances of vaccine adjuvants for infectious diseases

S Lee, MT Nguyen - Immune network, 2015 - ncbi.nlm.nih.gov
Vaccines are the most effective and cost-efficient method for preventing diseases caused by
infectious pathogens. Despite the great success of vaccines, development of safe and strong …

[HTML][HTML] Advances in infectious disease vaccine adjuvants

J Fan, S Jin, L Gilmartin, I Toth, WM Hussein… - Vaccines, 2022 - mdpi.com
Vaccines are one of the most significant medical interventions in the fight against infectious
diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the …

[HTML][HTML] Key roles of adjuvants in modern vaccines

SG Reed, MT Orr, CB Fox - Nature medicine, 2013 - nature.com
Vaccines containing novel adjuvant formulations are increasingly reaching advanced
development and licensing stages, providing new tools to fill previously unmet clinical …

Improving vaccines by incorporating immunological coadjuvants

CK Fraser, KR Diener, MP Brown… - Expert review of …, 2007 - Taylor & Francis
While vaccination continues to be the most successful interventionist health policy to date,
infectious disease remains a significant cause of death worldwide. A primary reason that …

New horizons in adjuvants for vaccine development

SG Reed, S Bertholet, RN Coler, M Friede - Trends in immunology, 2009 - cell.com
Over the last decade, there has been a flurry of research on adjuvants for vaccines, and
several novel adjuvants are now in licensed products or in late stage clinical development …

Vaccine adjuvants: smart components to boost the immune system

R Bastola, G Noh, T Keum, S Bashyal, JE Seo… - Archives of pharmacal …, 2017 - Springer
Vaccination is an effective approach to prevent the consequences of infectious diseases.
Vaccines strengthen immunity and make individuals resistant to infections with pathogens …

Survey of human-use adjuvants

R Edelman - Expert review of vaccines, 2003 - Taylor & Francis
Although there are only four adjuvants used in licensed vaccines for humans, a wealth of
information on novel vaccine adjuvants has become available in both animal models and …

The path to a successful vaccine adjuvant–'the long and winding road'

DT O'Hagan, E De Gregorio - Drug discovery today, 2009 - Elsevier
New generation vaccines will increasingly comprise highly purified recombinant proteins.
Unfortunately, these antigens are often poorly immunogenic. Therefore, adjuvants will be …

[HTML][HTML] The continued advance of vaccine adjuvants–'we can work it out'

DT O'Hagan, RN Lodaya, G Lofano - Seminars in immunology, 2020 - Elsevier
In the last decade there have been some significant advances in vaccine adjuvants,
particularly in relation to their inclusion in licensed products. This was proceeded by several …