Every week, articles disclosing new antifungal leads reported as promising starting points for
optimization projects are published. In many cases, the mechanism that accounts for their …

Pan-assay interference compounds (PAINS) are molecules showing promising but
deceptive activities in various biochemical screenings mainly due to unselective interactions …

While it is true that only a small fraction of fungal species are responsible for human
mycoses, the increasing prevalence of fungal diseases has highlighted an urgent need to …

Fungi are simple eukaryotic organisms that have colonized diverse environments around
the planet. There are approximately 2 million different species of fungi on the Earth [1]. Their …

This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …

To indicate the importance of fungal enzyme inhibitors (FEI) it is only required to mention
penicillin. However, many other natural products from fungi have been described …

Starting with the discovery of penicillin, the pharmaceutical industry has relied extensively
on natural products (NPs) as an unparalleled source of bioactive small molecules suitable …

The growing prevalence of antifungal drug resistance coupled with the slow development of
new, acceptable drugs and fungicides has raised interest in natural products (NPs) for their …

For a long time, fungal pathogens have been a threat to the health and diet of humans.
Consequently, antimycotic agents have been developed, which are called fungicides in …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …