Aldosterone itself has been reported to participate in mediating renal injury, and it was
confirmed that the aldosterone synthase CYP11B2 gene, protein, and aldosterone …

Administration of spironolactone provides a beneficial effect in various animal models of
renal injury. In this study, we investigated whether spironolactone prevents the progression …

Introduction. To investigate the beneficial effects of spironolactone (SPL) on glomerular
injury in streptozotocin (STZ)-induced diabetic rats and the possible mechanism. Methods …

In the last 10 years, many studies have focused on the non‐classical action of aldosterone.
One of the most important new aspects of aldosterone is its pathogenic role as …

Spironolactone (SPR), a mineralocorticoid receptor blocker, diminishes hyperglycemia-
induced reduction in glucose-6-phosphate dehydrogenase (G6PD) activity, improving …

Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory and
profibrotic cytokines. The effect of spironolactone on renal inflammation and renal function …

Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.
Background Glomerular and tubulointerstitial injury leads to chronic impairment of renal …

Background While there is an evidence that the anti-inflammatory properties of
spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular …

In this study, we examined the association between chronic kidney disease (CKD) and
insulin resistance. In a patient cohort with nondiabetic stages 2–5 CKD, estimated …

Aldosterone is increased in diabetes and contributes to the development of diabetic
nephropathy. The authors hypothesized that reduction in aldosterone production in diabetes …