Background: Estrogen deficiency contributes to the development of Alzheimer's disease
(AD) in menopausal women. In the current study, we examined the impact of estrogen …

Background Estrogen deficiency causes mitochondrial defects that precede pathological
changes related to Alzheimer's disease (AD) in the mouse model of postmenopause. The …

Previously, we demonstrated that reproductive senescence was associated with
mitochondrial deficits comparable to those of female triple-transgenic Alzheimer's mice …

Estrogen (E 2) deficiency is reported to involve in the impairment of cognition in
postmenopausal women. However, the morphological basis is still unclear. In the present …

Mitochondria play an important role in the synthesis of steroid hormones, including the sex
hormone estrogen. Sex-specific regulation of these hormones is important for phenotypic …

Mitochondria play an essential role in the generation of steroid hormones including the
female sex hormones. These hormones are, in turn, able to modulate mitochondrial …

In the present study, to determine whether aging could increase the vulnerability of the brain
to estrogen withdrawal-induced mitochondrial dysfunction, we measured the cytochrome c …

Cognitive dysfunction increases as menopause progresses. We previously found that
estrogen receptors (ERs) contribute to dyslipidemia, but the specific relationship between …

Postmenopausal women experience a higher risk for neurodegenerative diseases,
including cognitive impairment and ischemic stroke. Many preclinical studies have indicated …

Recently epidemiological studies suggest females lose neuroprotection from
neurodegenerative diseases as they go through menopause. It has been hypothesized that …