Objectives: The purpose of this study was to quantitatively assess the relationship between
therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in …

Background—Left ventricular remodeling, as commonly measured by left ventricular ejection
fraction (LVEF), is associated with clinical outcomes. Although change in LVEF over time …

Objectives: The objective of this study was to test the hypothesis that the severity of left
ventricular remodeling predicts the response to treatment and outcomes in chronic heart …

Background: A major advance in understanding the pathophysiology of the heart failure
syndrome has been an understanding of the process of left ventricular (LV) remodeling. After …

OBJECTIVES To assess the relation of left ventricular (LV) and left atrial (LA) dimensions,
ejection fraction (EF) and LV mass to subsequent clinical outcome of patients with LV …

Left ventricular (LV) remodeling (ie, enlargement and functional deterioration occurring over
time) is among the main mechanisms of progression in heart failure (HF). LV dilatation and …

Ventricular remodeling, first described in animal models of left ventricular (LV) stress and
injury, occurs progressively in untreated patients after large myocardial infarction and in …

Among patients with heart failure with reduced ejection fraction, investigators have
repeatedly identified a subgroup whose left ventricular ejection fraction and structural …

Background Three drug classes (mineralocorticoid receptor antagonists [MRAs], angiotensin
receptor–neprilysin inhibitors [ARNIs], and sodium/glucose cotransporter 2 [SGLT2] …

Background—Randomized trials have demonstrated the efficacy of several new therapies
for heart failure (HF) with reduced ejection fraction over the preceding 2 decades. This study …