[HTML][HTML] Teprotumumab in thyroid eye disease: wonder drug or great divider?

P Perros, L Hegedüs - European Thyroid Journal, 2023 - etj.bioscientifica.com
Progress in management of thyroid eye disease (TED) has been slow for many decades.
The recent introduction of teprotumumab (TEP) in the therapeutic arena for TED has had a …

The Efficacy and Safety of Teprotumumab in Thyroid Eye Disease: Evidence from Randomized Controlled Trials

F Lin, Q Yao, B Yu, Z Deng, J Qiu… - International Journal of …, 2023 - Wiley Online Library
In this study, we conducted a meta‐analysis to assess the efficacy and safety of
teprotumumab in treating thyroid eye disease. We searched the Cochrane Library, PubMed …

[HTML][HTML] Teprotumumab: a review in thyroid eye disease

T Nie, YN Lamb - Drugs, 2022 - Springer
Teprotumumab (TEPEZZA®), a monoclonal antibody that inhibits the insulin-like growth
factor 1 receptor (IGF-1R), is the first disease-modifying therapy approved for the treatment …

[HTML][HTML] Teprotumumab in clinical practice: recommendations and considerations from the OPTIC trial investigators

RS Douglas, Y Wang, RA Dailey… - Journal of Neuro …, 2021 - journals.lww.com
Background: Thyroid eye disease (TED) is a vision-threatening and debilitating condition
that until very recently had no Food and Drug Administration (FDA)-approved medical …

[HTML][HTML] Teprotumumab: interpreting the clinical trials in the context of thyroid eye disease pathogenesis and current therapies

BJ Winn, RC Kersten - Ophthalmology, 2021 - Elsevier
Teprotumumab, a monoclonal antibody targeted against the insulin-like growth factor 1 (IGF-
1) receptor, was recently approved by the United States Food and Drug Administration for …

Teprotumumab for the treatment of thyroid eye disease

P Fallahi, F Ragusa, SR Paparo, G Elia… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Thyroid eye disease (TED) is an autoimmune disease characterized by
inflammation of orbital and extraocular muscles. It induces proptosis and diplopia, leading to …

A perspective on the current role of teprotumumab in treatment of thyroid eye disease

RC Allen, EA Bradley, RG Fante, MJ Lucarelli - Ophthalmology, 2021 - aaojournal.org
The arrival of teprotumumab has been hailed as a gamechanger in the treatment of thyroid
eye disease (TED). 1 This monoclonal antibody to the insulin-like growth factor-1 receptor is …

[HTML][HTML] Expert consensus on the use of teprotumumab for the management of thyroid eye disease using a modified-delphi approach

RS Douglas, AL Kossler, J Abrams… - Journal of Neuro …, 2022 - journals.lww.com
Background: Teprotumumab is the first treatment for thyroid eye disease (TED), a debilitating
autoinflammatory condition, approved by the Food and Drug Administration in the United …

Long-Term Efficacy of Teprotumumab in Thyroid Eye Disease: Follow-Up Outcomes in Three Clinical Trials

GJ Kahaly, PS Subramanian, E Conrad, RJ Holt… - Thyroid, 2024 - liebertpub.com
Introduction: Thyroid eye disease (TED) is an autoimmune process characterized by
extraocular muscle and orbital fat remodeling/expansion resulting in swelling, pain, redness …

The role of teprotumumab in chronic, clinically active thyroid eye disease

CY Yu, BA Simmons, CM Pham, EM Shriver - Eye, 2022 - nature.com
Thyroid eye disease (TED) is a chronic inflammatory condition that can lead to permanent
disfigurement, disability, and vision loss. It is traditionally believed that TED is a self-limited …