Chemicals such as drugs, hormones, and odorants can have many potential interactions
with endogenous targets, and uncovering these relationships is critical for understanding …

G protein-coupled receptors (GPCRs) are central to how mammalian cells sense and
respond to chemicals. Mammalian olfactory receptors (ORs), the largest family of GPCRs …

Odorants create unique and overlapping patterns of olfactory receptor activation, allowing a
family of approximately 1,000 murine and 400 human receptors to recognize thousands of …

Identified ligands for> 500 mouse ORs ORs are specifically tuned towards individual
odorants and their molecular properties Odor molecular properties are informative of odor …

Deciphering olfactory encoding requires a thorough description of the ligands that activate
each odorant receptor (OR). In mammalian systems, however, ligands are known for fewer …

A multi-gene family of~ 1000 G protein-coupled olfactory receptors (ORs) constitutes the
molecular basis of mammalian olfaction. Due to the lack of structural data its remarkable …

G protein-coupled receptors (GPCRs) conserve common structural folds and activation
mechanisms, yet their ligand spectra and functions are highly diversified. This work …

The enormous sizes of the mammalian odorant receptor (OR) families present difficulties to
find their cognate ligands among numerous volatile chemicals. To efficiently and accurately …

Mammalian sense of smell is triggered by interaction between odorant molecules and a
class of proteins, called olfactory receptors (ORs). These receptors, expressed at the surface …

The mammalian olfactory system uses hundreds of specialized G-protein-coupled olfactory
receptors (ORs) to discriminate a nearly unlimited number of odorants. Cognate agonists of …