Amyotrophic lateral sclerosis (ALS) is an incurable neuromuscular disease that leads to a
profound loss of life quality and premature death. Around 10% of the cases are inherited and …

The VAP proteins are integral adaptor proteins of the endoplasmic reticulum (ER)
membrane that recruit a myriad of interacting partners to the ER surface. Through these …

ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB
(vesicle-associated membrane protein (VAMP)-associated membrane protein B)/ALS8). We …

The mutations P56S and T46I in the gene encoding vesicle-associated membrane protein-
associated protein B/C (VAPB) cause ALS8, a familial form of amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results
in the loss of motor function in the central nervous system (CNS) and ultimately death. The …

Amyotrophic lateral sclerosis is a progressive disease characterized by the loss of upper
and lower motor neurons, leading to paralysis of voluntary muscles. About 10% of all ALS …

The ability to reprogram adult somatic cells into pluripotent stem cells that can differentiate
into all three germ layers of the developing human has fundamentally changed the …

Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons
degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of …

Abstract Development of therapeutics for genetically complex neurodegenerative diseases
such as sporadic amyotrophic lateral sclerosis (ALS) has largely been hampered by lack of …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …