Abasic lesions are unable to form Watson− Crick hydrogen bonds with nucleotides.
Nonetheless, polymerase and repair enzymes distinguish between various oxidized abasic …

The C2 '-oxidized abasic lesion (C2-AP) is produced in DNA that is subjected to oxidative
stress. C2-AP is incised by phosphodiesterases, but is not a substrate for endonuclease III …

The C4′-oxidized abasic site (C4-AP), which is produced by a variety of damaging agents,
has significant consequences for DNA. The lesion is highly mutagenic and reactive …

Oxidative damage to DNA produces abasic sites resulting from the formal hydrolysis of the
nucleotides' glycosidic bonds, along with a variety of oxidized abasic sites. The C4 '-oxidized …

The C2′-oxidized abasic lesion (C2-AP) is produced in DNA that is subjected to oxidative
stress. The lesion disrupts replication and gives rise to mutations that are dependent upon …

2-Deoxyribonolactone (L) and the C4 '-oxidized abasic site (C4-AP) are produced by a
variety of DNA-damaging agents. If not repaired, these lesions can be mutagenic …

The recognition of 'regular'and 'oxidized'sites of base loss (AP sites) in DNA by various AP
endonucleases was compared. Model substrates with regular AP sites (resulting from mere …

A synthetic analog of an abasic site in DNA is efficiently repaired by a short-patch repair
mechanism in soluble extracts of Xenopus laevis oocytes (Y. Matsumoto and DF …

The C4′-oxidized abasic site (C4-AP) forms two types of interstrand cross-links with the
adjacent nucleotides in DNA. Previous experiments revealed that dG does not react with the …

The C4 '-oxidized abasic site (C4-AP) is produced by a variety of DNA damaging agents.
This alkali labile lesion can exist in up to four diastereomeric cyclic forms, in addition to the …