Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

Type-2 diabetes is associated with impaired glucose clearance by the liver in the
postprandial state, and with elevated glucose production in the post-absorptive state. New …

There has been an alarming increase in the population diagnosed with diabetes worldwide.
Although there is an ongoing debate as to the role of liver in the pathogenesis of diabetes …

We review mechanisms that regulate production of glucose by the liver, focusing on areas of
budding consensus, and endeavoring to provide a candid assessment of lingering …

The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …

Maintaining blood glucose concentration within a relatively narrow range through periods of
fasting or excess nutrient availability is essential to the survival of the organism. This is …

Increased hepatic glucose output, the primary liver dysregulation associated with Type 2
diabetes mellitus (T2DM), is not directly or effectively targeted by the currently available …

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs
and maintain an individual's health. The liver has a major role in the control of glucose …

Summary Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional
targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates …

Type 2 diabetes (T2D) is characterized by persistent hyperglycemia despite
hyperinsulinemia, affects more than 400 million people worldwide, and is a major cause of …