The Arp2/3 complex drives the formation of branched actin networks that are essential for
many cellular processes. In humans, the ARPC5 subunit of the Arp2/3 complex is encoded …

We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3
actin nucleator complex, in two unrelated patients presenting with recurrent and severe …

We report seven affected individuals from six families with a recurrent, de novo variant in the
ARPC4 gene (c. 472C> T [p. Arg158Cys (GenBank: NM_005718. 4)]). Core features in …

Regulation of the actin cytoskeleton is crucial for normal development and function of the
immune system, as evidenced by the severe immune abnormalities exhibited by patients …

Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …

The Arp2/3 complex regulates many cellular processes by stimulating formation of branched
actin filament networks. Because three of its seven subunits exist as two different isoforms …

CD4 T cell activation induces nuclear and cytoplasmic actin polymerization via the Arp2/3
complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling …

To the Editor: Recently, a novel syndrome of combined immunodeficiency, allergy, and
''auto''inflammation caused by mutations in the ARPC1B gene has been reported. 1-4 …

Recently, a novel syndrome of combined immune deficiency, infections, allergy, and
inflammation has been attributed to mutations in the gene encoding actin-related protein 2/3 …

Actin nucleators initiate formation of actin filaments. Among them, the Arp2/3 complex has
the ability to form branched actin networks. This complex is regulated by members of the …