Brain injury that results in an initial behavioural deficit is frequently followed by spontaneous
recovery. The intrinsic mechanism of this functional recovery has never been fully …

Promoting the rewiring of lesioned motor tracts following a spinal cord injury is a promising
strategy to restore motor function. For instance, axonal collaterals may connect to spared …

The corticospinal tract is an important target for motor recovery after spinal cord injury (SCI)
in animals and humans [1–5]. Voluntary motor output depends on the efficacy of synapses …

Neurotrophic factors have been proposed as a therapeutic treatment for traumatic brain and
spinal cord injury. The present study determined whether exogenous administration of one …

We reported recently that overexpression of neurotrophin-3 (NT-3) by motoneurons in the
spinal cord of rats will induce sprouting of corticospinal tract (CST) axons (Zhou et al.[2003] …

Previous experiments from our laboratory have shown that application of brain‐derived
neurotrophic factor (BDNF) to the red nucleus or the motor cortex stimulates an increase in …

Restoring corticospinal function after spinal cord injury is a significant challenge as the
corticospinal tract elicits no substantive, spontaneous regeneration, and its interruption …

Although regeneration of injured axons is inhibited within the adult CNS, moderate recovery
can be found in patients and animals with incomplete spinal cord injury (SCI). This can be …

Identification of the molecule (s) that globally induce a robust regenerative state in sensory
neurons following peripheral nerve injury remains elusive. A potential candidate is brain …

Spinal cord injury (SCI) is a devastating condition that affects approximately 294,000 people
in the USA and several millions worldwide. The corticospinal motor circuitry plays a major …