Abnormal intracellular metabolism not only provides nutrition for tumor occurrence and
development, but also sensitizes the function of various immune cells in the immune …

The overlapping metabolic reprogramming of cancer and immune cells is a putative
determinant of the antitumor immune response in cancer. Increased evidence suggests that …

Early and accurate diagnosis and treatment of pancreatic cancer (PC) remain challenging
endeavors globally. Late diagnosis lag, high invasiveness, chemical resistance, and poor …

Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor
cells and the number and activity of tumor-infiltrating T cells represent a good marker for …

Immunometabolism is an emerging discipline in cancer immunotherapy. Tumor tissues are
heterogeneous and influenced by metabolic reprogramming of the tumor immune …

Metabolic disorders and abnormal immune function changes occur in tumor tissues and
cells to varying degrees. There is increasing evidence that reprogrammed energy …

Pancreatic cancer (PC) has one of the highest fatality rates and the currently available
therapeutic options are not sufficient to improve its overall poor prognosis. In addition to …

Immune cells play a key role in host defense against infection and cancer. Upon
encountering danger signals, these cells undergo activation leading to a modulation in their …

It is notorious that cancer cells alter their metabolism to adjust to harsh environments of
hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor …

Fundamental metabolic pathways are essential for mammalian cells to provide energy,
precursors for biosynthesis of macromolecules, and reducing power for redox regulation …