STUDY QUESTION Can kisspeptin treatment induce gonadotrophin responses and
ovulation in preclinical models and anovulatory women with polycystic ovary syndrome …

Kisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate
hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin …

STUDY QUESTION Does direct kisspeptin signaling in the oocyte have a role in the control
of follicular dynamics and ovulation? SUMMARY ANSWER Kisspeptin signaling in the …

Polycystic ovary syndrome (PCOS) is a highly prevalent heterogeneous disease
characterized by ovulatory dysfunction, hyperandrogenism, and metabolic alterations …

Results The kisspeptin system (KISS1/G protein-coupled receptor-54, GPR54) has recently
been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion …

Premature ovarian failure (POF) affects 1% of women in reproductive age, but its etiology
remains uncertain. Whereas kisspeptins, the products of Kiss1 that act via Kiss1r (aka …

Kisspeptins are a family of hypothalamic neuropeptides that are essential for the regulation
of reproductive physiology. Their importance in reproductive health became apparent in …

The discovery of kisspeptins in the recent past remoulded current understanding of the
neuroendocrine axis relating to the regulation of human puberty and reproduction …

Kisspeptin is involved in the control of human reproduction bridging the gap between the
sex steroid levels and feedback mechanisms that control the gonadotropin releasing …

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …