Spermatogenesis, an intricate process occurring in the testis, is responsible for ongoing
production of spermatozoa and thus the cornerstone of lifelong male fertility. In the testis …

Introduction A decline in semen quality caused by global warming and torrid working
conditions is a major cause of human male infertility, and heat stress-induced decreases in …

The pineal hormone melatonin regulates testicular function through the hypothalamic-
adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis …

Infertility is a major global health issue and male factors account for half of all infertility
cases. One of the causes of male infertility is the loss of spermatogonial stem cells, which …

Normal spermatogenic processes require the scrotal temperature to be lower than that of the
body as excessive heat affects spermatogenesis in the testes, reduces sperm quality and …

Oxidative stress generates a large amount of reactive oxygen species (ROS) and affects
sperm quality via damaging sperm DNA and compromising the intracellular homeostasis in …

Background Modern societies face infertility as a global challenge. There are certain
environmental conditions and disorders that damage testicular tissue and may cause male …

It is widely accepted that oxidative stress (OS) coming from a wide variety of causes has
detrimental effects on male fertility. Antioxidants could have a significant role in the treatment …

Melatonin is a ubiquitous indoleamine hormone synthesized primarily by the pineal gland.
Diverse biological actions of melatonin involve quite complex mechanisms via its membrane …

Antioxidant actions of melatonin and its impact on testicular function and fertility have
already been described. Considering that Sertoli cells contribute to provide structural …