Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion
The nasopharynx and the skin are the major oxygen-rich anatomical sites for colonization by
the human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]). To establish …
the human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]). To establish …
Molecular and structural basis of glutathione import in Gram‐positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans
B Vergauwen, K Verstraete… - Molecular …, 2013 - Wiley Online Library
Glutathione (GSH) protects cells against oxidative injury and maintains a range of vital
functions across all branches of life. Despite recent advances in our understanding of the …
functions across all branches of life. Despite recent advances in our understanding of the …
Streptococcus pneumoniae uses glutathione to defend against oxidative stress and metal ion toxicity
AJ Potter, C Trappetti, JC Paton - Journal of bacteriology, 2012 - Am Soc Microbiol
The thiol-containing tripeptide glutathione is an important cellular constituent of many
eukaryotic and prokaryotic cells. In addition to its disulfide reductase activity, glutathione is …
eukaryotic and prokaryotic cells. In addition to its disulfide reductase activity, glutathione is …
Insights into Streptococcus Pyogenes Pathogenesis from Transcriptome Studies
T Fiedler, V Sugareva, N Patenge… - Future …, 2010 - Taylor & Francis
Streptococcus pyogenes (group A Streptococcus [GAS]) is a major human pathogen,
causing diseases ranging from mild superficial infections of the skin and pharyngeal …
causing diseases ranging from mild superficial infections of the skin and pharyngeal …
Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes
Neutrophils release free zinc to eliminate the phagocytosed bacterial pathogen
Streptococcus pyogenes (Group A Streptococcus; GAS). In this study, we investigated the …
Streptococcus pyogenes (Group A Streptococcus; GAS). In this study, we investigated the …
The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition
Sulfur is an indispensable element for bacterial proliferation. Prior studies demonstrated that
the human pathogen Staphylococcus aureus utilizes glutathione (GSH) as a source of …
the human pathogen Staphylococcus aureus utilizes glutathione (GSH) as a source of …
A critical role of zinc importer AdcABC in group A Streptococcus-host interactions during infection and its implications for vaccine development
Bacterial pathogens must overcome host immune mechanisms to acquire micronutrients for
successful replication and infection. Streptococcus pyogenes, also known as group A …
successful replication and infection. Streptococcus pyogenes, also known as group A …
Iron efflux by PmtA is critical for oxidative stress resistance and contributes significantly to group A Streptococcus virulence
AR VanderWal, N Makthal… - Infection and …, 2017 - Am Soc Microbiol
ABSTRACT Group A Streptococcus (GAS) is a human-only pathogen that causes a
spectrum of disease conditions. Given its survival in inflamed lesions, the ability to sense …
spectrum of disease conditions. Given its survival in inflamed lesions, the ability to sense …
Surface export of GAPDH/SDH, a glycolytic enzyme, is essential for Streptococcus pyogenes virulence
H Jin, S Agarwal, S Agarwal, V Pancholi - MBio, 2011 - Am Soc Microbiol
Streptococcal surface dehydrogenase (SDH)(glyceraldehyde-3-phosphate dehydrogenase
[GAPDH]) is an anchorless major multifunctional surface protein in group A Streptococcus …
[GAPDH]) is an anchorless major multifunctional surface protein in group A Streptococcus …
Interplay between group A Streptococcus and host innate immune responses
MSW Su, YL Cheng, YS Lin, JJ Wu - Microbiology and Molecular …, 2024 - Am Soc Microbiol
SUMMARY Group A Streptococcus (GAS), also known as Streptococcus pyogenes, is a
clinically well-adapted human pathogen that harbors rich virulence determinants …
clinically well-adapted human pathogen that harbors rich virulence determinants …