[HTML][HTML] Role of follicle-stimulating hormone in spermatogenesis

OO Oduwole, H Peltoketo, IT Huhtaniemi - Frontiers in endocrinology, 2018 - frontiersin.org
Spermatogenesis is a concerted sequence of events during maturation of spermatogonia
into spermatozoa. The process involves differential gene-expression and cell-cell interplay …

The endocrine regulation of spermatogenesis: independent roles for testosterone and FSH

RI McLachlan, NG Wreford, L O'donnell… - Journal of …, 1996 - joe.bioscientifica.com
Introduction The adult testis has two important roles, namely the production of spermatozoa
(fertility) and the secretion of testosterone which is needed for the expression of secondary …

[HTML][HTML] Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis

OO Oduwole, H Peltoketo, A Poliandri… - The Journal of …, 2018 - Am Soc Clin Investig
Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH)
and follicle-stimulating hormone (FSH). This process is considered impossible without the …

The role of follicle-stimulating hormone in spermatogenesis: lessons from knockout animal models

MR Sairam, H Krishnamurthy - Archives of medical research, 2001 - Elsevier
The development of knockout mouse models for the FSH-β subunit, the FSH receptor, and
LH-receptor performed in different laboratories has confirmed and extended our knowledge …

[HTML][HTML] Follicle-stimulating hormone (FSH) action on spermatogenesis: a focus on physiological and therapeutic roles

D Santi, P Crépieux, E Reiter, G Spaggiari… - Journal of Clinical …, 2020 - mdpi.com
Background: Human reproduction is regulated by the combined action of the follicle-
stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Although FSH …

[HTML][HTML] The roles of luteinizing hormone, follicle-stimulating hormone and testosterone in spermatogenesis and folliculogenesis revisited

OO Oduwole, IT Huhtaniemi, M Misrahi - International journal of molecular …, 2021 - mdpi.com
Spermatogenesis and folliculogenesis involve cell–cell interactions and gene expression
orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). FSH …

Hormonal control of germ cell development and spermatogenesis

PJ O'Shaughnessy - Seminars in cell & developmental biology, 2014 - Elsevier
Spermatogenesis is completely dependent on the pituitary hormone follicle-stimulating
hormone (FSH) and androgens locally produced in response to luteinising hormone (LH) …

A short evolutionary history of FSH-stimulated spermatogenesis

I Huhtaniemi - Hormones, 2015 - Springer
It is well established in various experimental models that luteinizing hormone (LH)
stimulated testosterone (T) production of Leydig cells is the key endocrine stimulus of …

Impairing follicle-stimulating hormone (FSH) signaling in vivo: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance

A Dierich, MR Sairam, L Monaco… - Proceedings of the …, 1998 - National Acad Sciences
Pituitary gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone
stimulate the gonads by regulating germ cell proliferation and differentiation. FSH receptors …

[HTML][HTML] Endocrinology of the male reproductive system and spermatogenesis

L O'Donnell, P Stanton, DM de Kretser - 2015 - europepmc.org
The testes synthesize two important products: testosterone, needed for the development and
maintenance of many physiological functions; and sperm, needed for male fertility. The …