Delivering therapeutic agents to the lungs requires a deep understanding of the kinetics and
dynamics of drugs in this biologically and physiologically complex system. In this chapter …

A compartmental model is presented which describes the release of drug from a carrier
deposited in the human respiratory tract and the clearance of the drug by mucociliary and …

As the end organ for the treatment of local diseases or as the route of administration for
systemic therapies, the lung is a very attractive target for drug delivery. It provides direct …

Although there is a modest body of literature on the absorption of inhaled pharmaceuticals
by normal lungs and some limited information from diseased lungs, there is still a surprising …

Publisher Summary In this chapter, a brief outline of the human respiratory system is
provided, and mechanisms of drug particle deposition in human lungs, various pulmonary …

Peptide and protein drugs are being used increasingly in major research and development
programs in the pharmaceutical industry and are also an important class of therapeutic …

The inhalation route is frequently used to administer drugs for the management of
respiratory diseases such as asthma or chronic obstructive pulmonary disease. Compared …

Introduction: Over the past years, a significant number of papers have substantiated earlier
findings proposing a role for drug transporter proteins in pulmonary drug disposition. Whilst …

The origins of inhalation therapy can be traced back to the early civilizations but this route of
administration was relatively uncommon until recently. Direct delivery of drugs to the lung by …

KINETIC ASPECTS OF DRUG, DISPOSITION IN THE LUNGS Page 1 Clinical and
Experimental Pharmacology and Physiology (1999) 26, 381–391 BRIEF REVIEW KINETIC …