Following T cell receptor triggering, T cell activation is initiated and amplified by the
assembly at the TCR/CD3 macrocomplex of a multitude of stimulatory enzymes that activate …

T cells are critical components of adaptive immunity. As such, their activation is regulated by
the T cell receptor (TCR) that constantly scan peptides associated with major …

Background Adequate termination of an immune response is as important as the induction
of an appropriate response. CD46, a regulator of complement activity, promotes T cell …

Background CD6 is one of many cell surface receptors known to regulate signal
transduction upon T cell activation. However, whether CD6 mediates costimulatory or …

Activation of the T cell receptor (TCR) on the T cell through ligation with antigen-MHC
complex of an antigen-presenting cell (APC) is an essential process in the activation of T …

CD6 immunotherapy to treat psoriasis and rheumatoid arthritis has reached the clinical trial
stage with apparent success, and targeting CD6 with mAbs is being used in several animal …

CD5 is characterized as an inhibitory coreceptor with an important regulatory role during T
cell development. The molecular mechanism by which CD5 operates has been puzzling and …

The essential function of the T cell receptor (TCR) is to translate the engagement of peptides
on the major histocompatibility complex (pMHC) into appropriate intracellular signals …

The great majority of mammalian genes yield multiple transcripts arising from differential
mRNA processing, but in very few instances have alternative forms been assigned distinct …

The T cell marker CD6 regulates both T cells and target cells during inflammatory responses
by interacting with its receptors. However, only a few receptors binding to the extracellular …