Pruritus is the most common symptom of dermatological disorders, and prurigo nodularis
(PN) is notorious for intractable and severe itching. Conventional treatments often yield …

Chronic pruritus that lasts for over 6 weeks can present in various forms, like papules,
nodules, and plaque types, with prurigo nodularis (PN) being the most prevalent. The …

Chronic nodular prurigo (CNPG) is a recalcitrant chronic itchy disorder that affects the quality
of life. It can be triggered by multiple etiologies, such as atopic dermatitis, diabetes, and …

Pruritus or itch generated in the skin is one of the most widespread symptoms associated
with various dermatological and systemic (immunological) conditions. Although many details …

Prurigo nodularis (PN) is a chronic, recalcitrant inflammatory skin condition characterized by
the presence of pruritic nodules. The exact pathogenesis of the disease is unknown …

Chronic pruritus (of more than 6 weeks duration) is one of the most frequent and
burdensome of symptoms, occurring not only in association with a variety of dermatoses but …

Pruritoceptive (dermal) itch was long considered an accompanying symptom of diseases, a
side effect of drug applications, or a temporary sensation induced by invading pruritogens …

The underlying mechanisms of chronic pruritus (CP), which is often very debilitating for
patients, are still not well understood. Over the past few years, peripheral and central …

Pruritus is defined as a unpleasant sensation that causes a desire to scratch. It may
accompany various skin diseases, but it may also be present in many systemic, neurologic …

Introduction Chronic pruritus is non-histaminergic and mediated through a complex interplay
of peripheral and central immune and neural pathways. Significant developments in the …