Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to
model human cancer metastasis in vivo. Here we describe mouse models of high-grade …

Recent evidence suggests that ovarian high‐grade serous carcinoma (HGSC) originates
from the epithelium of the fallopian tube. However, most mouse models are based on the …

High-grade serous ovarian cancer (HGSC) is the leading cause of morbidity and mortality
from gynecologic malignant tumors. Overall survival remains low because of the nearly …

Serous epithelial ovarian cancer (SEOC) is the most lethal gynecological cancer in the
United States with disease recurrence being the major cause of morbidity and mortality …

High-grade serous epithelial ovarian cancer (HGSC) is the most aggressive subtype of
epithelial ovarian cancer. The identification of germline and somatic mutations along with …

The high mortality rate from ovarian cancers can be attributed to late-stage diagnosis and
lack of effective treatment. Despite enormous effort to develop better targeted therapies …

Although named “ovarian cancer,” it has been unclear whether the cancer actually arises
from the ovary, especially for high-grade serous carcinoma (HGSC), also known as high …

Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known
about how the cancer initiates and metastasizes. In the last decade, new evidence has …

Epithelial ovarian cancer (OC) is often diagnosed at an advanced stage with peritoneal
metastasis, and preclinical models mimicking the natural course of OC peritoneal metastasis …

The development of preclinical spontaneous genetically engineered mouse models
(GEMMs) requires an understanding of the genetic basis of the human disease. Such robust …