Introduction 3. Asialoglycoprotein receptor 3.1. Biology of asialoglycoprotein receptor (ASGP-
R) 3.2. Carbohydrate recognition domain (CRD) 3.3 Internalization of the ligands by ASGP …

Hepatocyte resident afflictions continue to affect the human population unabated. The
asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally …

Standard pharmacologic approaches to liver diseases have been frustrated by inadequate
delivery of active agents into liver cells as well as nonspecific toxicity towards other organs …

We synthesized three novel galactosylated cholesterol derivatives, cholesten-5-yloxy-N-(4-
((1-imino-c-β-D-thiogalactosyl-ethyl) amino) butyl) formamide (Gal-C4-Chol) and its ethyl …

Targeted delivery of therapeutic agents to hepatocytes is a particularly attractive strategy for
the treatment of hepatocellular carcinoma and other liver diseases. The asialoglycoprotein …

Highly efficient, specific, and nontoxic gene delivery vector is required for gene therapy to
the liver. Hepatocytes exclusively express asialoglycoprotein receptor (ASGPR), which can …

Naturally existing cell surface receptors provide convenient systems for transporting
substances from the extracellular environment to the interior of cells. When such receptors …

The insult to liver by toxic materials leads to cirrhosis, hepatitis and cancer. Upon
administration, drugs accumulate in liver, which is systemically cleared by …

Purpose. To investigate the effects of the lipid composition of galactosylated liposomes on
their targeted delivery to hepatocytes. Methods. Several types of liposomes with a particle …

Unilamellar activated cationic liposomes containing 3β [N-(N′, N′-dimethylaminopropane
)-carbamoyl] cholesterol, dioleoyl phosphatidylethanolamine (DOPE) and the N …