KATP channels of primary human coronary artery endothelial cells consist of a heteromultimeric complex of Kir6. 1, Kir6. 2, and SUR2B subunits

H Yoshida, JE Feig, A Morrissey, IA Ghiu… - Journal of molecular and …, 2004 - Elsevier
Functional ATP-sensitive potassium (KATP) channels can be reconstituted by expression of
various combinations of different pore-forming subunits (Kir6. 1 and Kir6. 2) and sulfonylurea …

Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6. 2 and SUR2A

E Lorenz, A Terzic - Journal of molecular and cellular cardiology, 1999 - Elsevier
The inwardly-rectifying K+ channel Kir6. 2 serves as a common pore-forming core in various
ATP-sensitive K+ (KATP) channels, and it is through assembly with sulfonylurea-receptor …

Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits

L Bao, K Hadjiolova, WA Coetzee… - American Journal of …, 2011 - journals.physiology.org
ATP-sensitive K+ (KATP) channels, composed of inward rectifier K+ (Kir) 6. x and
sulfonylurea receptor (SUR) x subunits, are expressed on cellular plasma membranes. We …

Selective expression of Kir6. 1 protein in different vascular and non-vascular tissues

X Sun, K Cao, G Yang, Y Huang, ST Hanna… - Biochemical …, 2004 - Elsevier
KATP channels are composed of pore-forming subunits Kir6. x and auxiliary subunits SURx.
These channels play important roles in modulating the contractility of vascular smooth …

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature

A Morrissey, E Rosner, J Lanning, L Parachuru… - BMC physiology, 2005 - Springer
Background Electrophysiological data suggest that cardiac K ATP channels consist of Kir6. 2
and SUR2A subunits, but the distribution of these (and other K ATP channel subunits) is …

Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6. 2-knockout mice

M Suzuki, RA Li, T Miki, H Uemura… - Circulation …, 2001 - Am Heart Assoc
ATP-sensitive potassium (KATP) channels were discovered in ventricular cells, but their
roles in the heart remain mysterious. KATP channels have also been found in numerous …

Reconstituted Human Cardiac KATP Channels: Functional Identity With the Native Channels From the Sarcolemma of Human Ventricular Cells

AP Babenko, G Gonzalez, L Aguilar-Bryan… - Circulation …, 1998 - Am Heart Assoc
ATP-sensitive potassium (KATP) channels in striated myocytes are heteromultimers of KIR6.
2, a weak potassium inward rectifier, plus SUR2A, a low-affinity sulfonylurea receptor. We …

ATP‐Sensitive K+ Channels of Vascular Smooth Muscle Cells

WC Cole… - Journal of cardiovascular …, 2003 - Wiley Online Library
ATP‐sensitive potassium channels (KATP) of vascular smooth muscle cells represent
potential therapeutic targets for control of abnormal vascular contractility. The biophysical …

Evidence against Functional Heteromultimerization of theK ATP Channel Subunits Kir6. 1 and Kir6. 2

J Seharaseyon, N Sasaki, A Ohler, T Sato… - Journal of Biological …, 2000 - ASBMB
K ATP channels consist of pore-forming potassium inward rectifier (Kir6. x) subunits and
sulfonylurea receptors (SURs). Although Kir6. 1 or Kir6. 2 coassemble with different SUR …

Pore loop-mutated rat KIR6.1 and KIR6.2 suppress KATP current in rat cardiomyocytes

L van Bever, S Poitry, C Faure… - American Journal …, 2004 - journals.physiology.org
Cardiomyocytes express mRNA for all major subunits of ATP-sensitive potassium (KATP)
channels: KIR6. 1, KIR6. 2, SUR1A, SUR2A, and SUR2B. It has remained controversial as to …