Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …

Acute postoperative pain is followed by persistent pain in 10–50% of individuals after
common operations, such as groin hernia repair, breast and thoracic surgery, leg …

Importance Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis
that started in North America and spread throughout high-income countries. The aim of this …

Worldwide, the use of prescription opioid analgesics more than doubled between 2001 and
2013, with several countries, including the USA, Canada, and Australia, experiencing …

Physicians, policymakers, and researchers are increasingly focused on finding ways to
decrease opioid use and overdose in the United States both of which have sharply …

Although postoperative pain remains incompletely controlled in some settings, increased
understanding of its mechanisms and the development of several therapeutic approaches …

Postanaesthesia care units used to echo with cries of patients in pain after general
anaesthesia. Each as-needed dose of analgesia was given only after permission of the …

Opioids are a mainstay of acute pain management but can have many adverse effects,
contributing to problematic long-term use. Opioid tolerance (increased dose needed for …

Abstract Purpose of Review The opioid crisis most likely is the most profound public health
crisis our nation has faced. In 2015 alone, 52,000 people died of drug overdoses, with over …

The opioid epidemic has resulted from myriad causes and will not be solved by any simple
solution. Consequent to a staggering increase in opioid-related deaths in the USA, various …