Neonates face heightened susceptibility to drug toxicity, often exposed to off-label
medications with dosages extrapolated from adult or pediatric studies. Premature infants in …

Objectives: Neonates admitted to the neonatal intensive care unit (NICU) are at greater risk
of permanent hearing loss compared to infants in well mother and baby units. Several …

Background Neonates admitted to neonatal intensive care units (NICU) are exposed to a
wide variety of drugs, most without any data on safety and efficacy. Objective: To describe …

Aim: To determine relationships between ototoxic drugs and 4‐y sensorineural hearing loss
(SNHL) in near‐term and term survivors of severe neonatal respiratory failure. Methods: All …

In 2007, the American Academy of Pediatrics (AAP) published a position statement
regarding hearing screening in neonates which stated that “all infants with a risk indicator for …

INTRODUCTION—The main concerns with the use of aminoglycoside antibiotics are
nephrotoxicity and ototoxicity. This topic will review what is known about the pathogenesis of …

Background: Aminoglycoside-induced ototoxicity has been reported in neonates but its
incidence is poorly defined, whereas vancomycin-induced ototoxicity has not been reported …

Background Drug use in preterm neonates admitted to Neonatal Intensive Care Unit (NICU)
has been investigated, so far, in terms of unauthorized or off-label use; very little is known on …

Abstract From World Health Organization data, the prevalence of hearing impairment among
infants varies between 0.5 and 3.0 cases per thousand, but in children hospitalized in the …

Toxicity has limited the use of aminoglycosides and adult studies report high rates of both
ototoxicity and nephrotoxicity. Conversely paediatric studies have shown lower rates and …