Existing drug delivery methods have not led to a significant increase in survival for patients
with malignant primary brain tumors. While the combination of conventional therapies …

Even though the last decade has seen a surge in the identification of molecular targets and
targeted therapies in pediatric brain tumors, the blood brain barrier (BBB) remains a …

The presence of barriers, such as the blood–brain barrier (BBB) and brain–tumor barrier
(BTB), limits the penetration of antineoplastic drugs into the brain, resulting in poor response …

Glioblastoma (GBM) is the most common primary brain tumor and carries a grave prognosis.
Despite years of research investigating potentially new therapies for GBM, the median …

Treatment of malignant gliomas represents one of the most formidable challenges in
oncology. Despite treatment with surgery, radiation therapy, and chemotherapy, the …

The majority of newly diagnosed brain tumors are treated with surgery, radiation, and the
chemotherapeutic temozolomide. Development of additional therapeutics to improve …

Gliomas are amongst the most insidious and destructive types of brain cancer and are
associated with a poor prognosis, frequent recurrences, and extremely high lethality despite …

Glioblastoma (GBM) is the most common and lethal primary brain tumor which is highly
resistant to conventional radiotherapy and chemotherapy, and cannot be effectively …

Effective treatments for brain tumors remain one of the most urgent and unmet needs in
modern oncology. This is due not only to the presence of the neurovascular unit/blood–brain …

Introduction: Brain tumors represent one of the most challenging and difficult areas in unmet
medical needs. Fortunately, the past decade has seen momentous developments in brain …