Family-based designs continue to be valuable for establishing evidence of causal
relationships in studies of substance use disorders and other mental health conditions. In …

Aims In this exciting era of gene discovery, we review evidence from family, adoption and
twin studies that examine the genetic basis for addiction. With a focus on the classical twin …

Background and Objectives Given moderate heritability and significant heterogeneity among
addiction phenotypes, successful genome‐wide association studies (GWAS) are expected …

Meta-analyses of genome-wide association study data have begun to lead to promising new
discoveries for behavioral and psychiatrically relevant phenotypes (eg, schizophrenia …

Genetic association studies, in particular candidate gene studies, have a long history of
initially promising findings which subsequently produce a confusing mixture of replications …

This study presents results from a collaboration across five longitudinal studies seeking to
test and replicate models of gene–environment interplay in the development of substance …

There is considerable enthusiasm for the potential of genetics research for prevention and
treatment of addiction and other mental disorders. As a result, clinicians are increasingly …

The advent of molecular genetics might seem to have reduced the importance of twin
studies, but in many ways, their utility has greatly increased instead. We first clarify the …

Background Vulnerabilities to dependence on addictive substances are substantially
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …

The genetics of addictions including alcohol dependence have been the focus of extensive
research, albeit with variable and often conflicting results. Heritability estimations suggest …