[HTML][HTML] The toxicity and polymorphism of β-amyloid oligomers

Y Huang, R Liu - International journal of molecular sciences, 2020 - mdpi.com
It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …

Molecular mechanisms of amyloid oligomers toxicity

R Kayed, CA Lasagna-Reeves - Journal of Alzheimer's …, 2013 - content.iospress.com
Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This
hypothesis might explain the lack of correlation between amyloid plaques and memory …

[HTML][HTML] An unbalanced synaptic transmission: cause or consequence of the amyloid oligomers neurotoxicity?

M Sciaccaluga, A Megaro, G Bellomo… - International Journal of …, 2021 - mdpi.com
Amyloid-β (Aβ) 1-40 and 1-42 peptides are key mediators of synaptic and cognitive
dysfunction in Alzheimer's disease (AD). Whereas in AD, Aβ is found to act as a pro …

Amyloid‐β oligomers in cellular models of Alzheimer's disease

IC Fontana, AR Zimmer, AS Rocha… - Journal of …, 2020 - Wiley Online Library
Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in
Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to …

[HTML][HTML] Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease

ST Ferreira, MV Lourenco, MM Oliveira… - Frontiers in cellular …, 2015 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

Neurotoxicity of β-amyloid protein: oligomerization, channel formation and calcium dyshomeostasis

M Kawahara - Current pharmaceutical design, 2010 - ingentaconnect.com
Numerous studies have indicated that Alzheimer's amyloid-β protein (Aβ) causes the
degeneration of synapses and neurons, finally inducing the pathogenesis of Alzheimer's …

Amyloid oligomers: formation and toxicity of Aβ oligomers

M Sakono, T Zako - The FEBS journal, 2010 - Wiley Online Library
Alzheimer's disease (AD) is an age‐related, progressive degenerative disorder that is
characterized by synapse and neuron loss in the brain and the accumulation of protein …

Different conformations of amyloid β induce neurotoxicity by distinct mechanisms in human cortical neurons

A Deshpande, E Mina, C Glabe… - Journal of …, 2006 - Soc Neuroscience
Characterization of soluble oligomeric amyloid β (Aβ) species in the brains of Alzheimer's
disease (AD) patients and transgenic models has raised the possibility that different …

[HTML][HTML] Cellular receptors of amyloid β oligomers (AβOs) in Alzheimer's disease

B Mroczko, M Groblewska, A Litman-Zawadzka… - International journal of …, 2018 - mdpi.com
It is estimated that Alzheimer's disease (AD) affects tens of millions of people, comprising not
only suffering patients, but also their relatives and caregivers. AD is one of age-related …

[HTML][HTML] Oligomerization and conformational change turn monomeric β-amyloid and tau proteins toxic: Their role in Alzheimer's pathogenesis

B Penke, M Szűcs, F Bogár - Molecules, 2020 - mdpi.com
The structural polymorphism and the physiological and pathophysiological roles of two
important proteins, β-amyloid (Aβ) and tau, that play a key role in Alzheimer's disease (AD) …