Right ventricular failure in idiopathic pulmonary arterial hypertension is associated with inefficient myocardial oxygen utilization

YY Wong, G Ruiter, M Lubberink… - Circulation: Heart …, 2011 - Am Heart Assoc
Background—In idiopathic pulmonary arterial hypertension (IPAH), increased right
ventricular (RV) power is required to maintain cardiac output. For this, RV O2 consumption …

Systolic pulmonary artery pressure and heart rate are main determinants of oxygen consumption in the right ventricular myocardium of patients with idiopathic …

YY Wong, N Westerhof, G Ruiter… - European journal of …, 2011 - Wiley Online Library
Aims Increased afterload in idiopathic pulmonary arterial hypertension (IPAH) causes right
ventricular (RV) hypertrophy and failure. Since RV remodelling occurs with alterations in RV …

Impaired right ventricular lusitropy is associated with ventilatory inefficiency in pulmonary arterial hypertension

K Tello, A Dalmer, R Vanderpool… - European …, 2019 - Eur Respiratory Soc
Cardiopulmonary exercise testing (CPET) is an important tool for assessing functional
capacity and prognosis in pulmonary arterial hypertension (PAH). However, the associations …

The right ventricle in pulmonary arterial hypertension

R Naeije, A Manes - European respiratory review, 2014 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH,
the right ventricle tends to remain adapted to afterload with increased contractility and little …

Right ventricular concentric hypertrophy and clinical worsening in idiopathic pulmonary arterial hypertension

R Badagliacca, R Poscia, B Pezzuto, S Papa… - The Journal of Heart and …, 2016 - Elsevier
Background Because the pathophysiology of idiopathic pulmonary arterial hypertension
(IPAH) is an afterload mismatch, wall stress represents the most important feature affecting …

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

S Rain, ML Handoko, P Trip, CTJ Gan, N Westerhof… - Circulation, 2013 - Am Heart Assoc
Background—The role of right ventricular (RV) diastolic stiffness in pulmonary arterial
hypertension (PAH) is not well established. Therefore, we investigated the presence and …

Right ventricular and right atrial function are less compromised in pulmonary hypertension secondary to heart failure with preserved ejection fraction: a comparison …

J van Wezenbeek, A Kianzad… - Circulation: Heart …, 2022 - Am Heart Assoc
Background: Heart failure with preserved ejection fraction (HFpEF) is a prevalent disorder
for which no effective treatment yet exists. Pulmonary hypertension (PH) and right atrial (RA) …

Signs of right ventricular deterioration in clinically stable patients with pulmonary arterial hypertension

MC Van De Veerdonk, JT Marcus, N Westerhof… - Chest, 2015 - Elsevier
BACKGROUND: Even after years of stable response to therapy, patients with idiopathic
pulmonary arterial hypertension (IPAH) may show an unexpected clinical deterioration due …

Right ventricular remodeling in idiopathic pulmonary arterial hypertension: adaptive versus maladaptive morphology

R Badagliacca, R Poscia, B Pezzuto, M Nocioni… - The Journal of Heart and …, 2015 - Elsevier
Background Although increased pulmonary pressure is caused by changes in the
pulmonary vasculature, prognosis in idiopathic pulmonary arterial hypertension (IPAH) is …

Right ventricular functional reserve in pulmonary arterial hypertension

S Hsu, BA Houston, E Tampakakis, AC Bacher… - Circulation, 2016 - Am Heart Assoc
Background—Right ventricular (RV) functional reserve affects functional capacity and
prognosis in patients with pulmonary arterial hypertension (PAH). PAH associated with …