Test–retest reliability and concurrent validity of in vivo myelin content indices: Myelin water fraction and calibrated T1w/T2w image ratio

M Arshad, JA Stanley, N Raz - Human brain mapping, 2017 - Wiley Online Library
In an age‐heterogeneous sample of healthy adults, we examined test–retest reliability (with
and without participant repositioning) of two popular MRI methods of estimating myelin …

Reproducibility of in vivo magnetic resonance imaging–based measurement of myelin water

IR Levesque, CLL Chia, GB Pike - Journal of Magnetic …, 2010 - Wiley Online Library
Purpose: To evaluate the reproducibility of multicomponent quantitative T2 (QT2)
measurements, in particular the myelin water fraction (MWF), to determine the sensitivity of …

Can T1w/T2w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T1w/T2w ratios, GRASE‐based T1w/T2w ratios …

MN Uddin, TD Figley, RA Marrie, CR Figley… - NMR in …, 2018 - Wiley Online Library
Given the growing popularity of T 1‐weighted/T 2‐weighted (T 1w/T 2w) ratio
measurements, the objective of the current study was to evaluate the concordance between …

Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis

J O'Muircheartaigh, I Vavasour… - Human Brain …, 2019 - Wiley Online Library
Quantitative magnetic resonance imaging (MRI) techniques have been developed as
imaging biomarkers, aiming to improve the specificity of MRI to underlying pathology …

Multicenter measurements of myelin water fraction and geometric mean T2: Intra‐ and intersite reproducibility

SM Meyers, IM Vavasour, B Mädler… - Journal of Magnetic …, 2013 - Wiley Online Library
Purpose To assess the reproducibility of myelin water fraction (MWF) and geometric mean
T2 (GMT2), which are in vivo markers of pathological changes underlying disability and …

Comparisons between multi-component myelin water fraction, T1w/T2w ratio, and diffusion tensor imaging measures in healthy human brain structures

MN Uddin, TD Figley, KG Solar, AS Shatil, CR Figley - Scientific reports, 2019 - nature.com
Various MRI techniques, including myelin water imaging, T1w/T2w ratio mapping and
diffusion-based imaging can be used to characterize tissue microstructure. However …

Myelin water and T2 relaxation measurements in the healthy cervical spinal cord at 3.0 T: repeatability and changes with age

EL MacMillan, B Mädler, N Fichtner, MF Dvorak, DKB Li… - Neuroimage, 2011 - Elsevier
Multiecho T2 relaxation measurements offer specific information about myelin content
through the myelin water fraction (MWF), as well as about the water environments through …

An atlas for human brain myelin content throughout the adult life span

AV Dvorak, T Swift-LaPointe, IM Vavasour, LE Lee… - Scientific reports, 2021 - nature.com
Myelin water imaging is a quantitative neuroimaging technique that provides the myelin
water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular …

Effect of intercompartmental water exchange on the apparent myelin water fraction in multiexponential T2 measurements of rat spinal cord

KD Harkins, AN Dula, MD Does - Magnetic resonance in …, 2012 - Wiley Online Library
The myelin water fraction has been used as a quantitative measure of the amount of myelin
present in tissue. However, recent work has suggested that intercompartmental exchange of …

Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods

A Hagiwara, M Hori, K Kamagata, M Warntjes… - Scientific reports, 2018 - nature.com
Magnetization transfer (MT) imaging has been widely used for estimating myelin content in
the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R1 …