Phosphoinositide 3-kinases (PI 3-Ks) 1 are a subfamily of lipid kinases that catalyze the
addition of a phosphate molecule specifically to the 3-position of the inositol ring of …

Phosphoinositide 3-kinase (PI3K) is an enzyme that participates in a myriad of cellular
processes and whose activity has been linked to cell growth and transformation …

It is now clear that lipid phosphorylation and hydrolysis plays a pivotal role in the
transmission of extracellular stimuli across the cytoplasm [1, 2]. Consequently, great effort …

Since its first identification in preparations of oncogenic protein tyrosine kinases, the PI 3-
kinase has been postulated to be an important component in growth regulation1, 2. The …

Phosphoinositide lipids regulate numerous cellular processes in all eukaryotes. The
versatility of this phospholipid is provided by combinations of phosphorylation on the 3 …

Abstract Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-
stimulated signalling and in the regulation of membrane traffic. Several distinct classes of …

Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3′ position
of the inositol ring on phosphatidylinositol and higher-phosphorylated …

Inositol phospholipids regulate a variety of cellular processes including proliferation,
survival, vesicular trafficking, and cytoskeletal organization. Recently, two novel …

The importance of phosphoinositides as lipid signaling molecules in eucaryotic cells was
first recognized by Lowell and Mabel Hokin in the 1950s (who also discovered the enzyme …

In eukaryotic cells, phosphatidylinositol can be phosphorylated on the inositol ring by a
series of kinases to produce at least seven distinct phosphoinositides. These lipids have …