[HTML][HTML] Immune system and hepatocellular carcinoma (HCC): new insights into HCC progression

M Kotsari, V Dimopoulou, J Koskinas… - International Journal of …, 2023 - mdpi.com
According to the WHO's recently released worldwide cancer data for 2020, liver cancer
ranks sixth in morbidity and third in mortality among all malignancies. Hepatocellular …

[HTML][HTML] New therapeutics for HCC: does tumor immune microenvironment matter?

A Khanam, S Kottilil - International Journal of Molecular Sciences, 2022 - mdpi.com
The incidence of liver cancer is continuously rising where hepatocellular carcinoma (HCC)
remains the most common form of liver cancer accounting for approximately 80–90% of the …

Hepatocellular carcinoma tumor microenvironment and its implications in terms of anti-tumor immunity: Future perspectives for new therapeutics

B Satilmis, TT Sahin, E Cicek, S Akbulut… - Journal of Gastrointestinal …, 2021 - Springer
Purpose Hepatocellular cancer is an insidious tumor that is often diagnosed in a later stage
of life. The tumor microenvironment is the key to tumorigenesis and progression. Many …

[HTML][HTML] Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options

Z Sas, E Cendrowicz, I Weinhäuser… - International Journal of …, 2022 - mdpi.com
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

[HTML][HTML] Targeting immune cells in the tumor microenvironment of HCC: new opportunities and challenges

X Hao, G Sun, Y Zhang, X Kong, D Rong… - Frontiers in cell and …, 2021 - frontiersin.org
Immune associated cells in the microenvironment have a significant impact on the
development and progression of hepatocellular carcinoma (HCC) and have received more …

Tumor microenvironment in hepatocellular carcinoma: key players for immunotherapy

H Feng, Y Zhuo, X Zhang, Y Li, Y Li… - Journal of …, 2022 - Taylor & Francis
Hepatocellular carcinoma (HCC) remains a serious medical therapeutic challenge as
conventional curative avenues such as surgery and chemotherapy only benefit for few …

The immunosuppressive tumor microenvironment in hepatocellular carcinoma-current situation and outlook

Z Zhou, Y Hu, Y Wu, Q Qi, J Wang, L Chen… - Molecular Immunology, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most severe malignant tumors that threaten
human health, and its incidence is still on the rise recently. In spite of the current emerging …

[HTML][HTML] Recent advances: The imbalance of immune cells and cytokines in the pathogenesis of hepatocellular carcinoma

K Jayant, N Habib, KW Huang, J Warwick… - Diagnostics, 2020 - mdpi.com
Recent advancement in the immunological understanding of genesis of hepatocellular
carcinoma (HCC) has implicated a decline in anti-tumour immunity on the background of …

[HTML][HTML] Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …

[HTML][HTML] The effect of liver disease on hepatic microenvironment and implications for immune therapy

ZJ Brown, SM Ruff, TM Pawlik - Frontiers in Pharmacology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fourth
leading cause of cancer-related death worldwide. HCC often occurs in the setting of chronic …